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Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone and Prednisolone are considered to be intermediate acting steroids, meaning that a dose lasts about a day or a day and a half. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical.
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